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PIK3C3 / VPS34

phosphatidylinositol 3-kinase, catalytic subunit type 3

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.

Gene Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
Family/Subfamily: Non-Protein Kinase , not assigned-Non-Protein Kinase
Synonyms: PIK3C3, HVps34, Phosphatidylinositol 3-kinase, VPS34, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3
Target Sequences: NM_002647 NP_002638.2 Q8NEB9

Publications (1)

1
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R. Cell death and differentiation. 2008 15:1318-29. [PubMed:18421301] Related Antibodies: LS-C163703.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
PIK3C3 / VPS34 (5)
No (5)
GST (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
PIK3C3 / VPS34 Protein - Recombinant  Phosphoinositide-3-Kinase Class 3 By SDS-PAGE
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E. coli
His, N-Terminal
32.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
PIK3C3 / VPS34 Protein - 12.5% SDS-PAGE of human PIK3C3 stained with Coomassie Blue
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Wheat Germ Extract
GST
127.9 kDa
10 µg/$479; 25 µg/$670
PIK3C3 / VPS34 Protein - Purified recombinant protein PIK3C3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
101.4 kDa
20 µg/$1,107
PIK3C3 / VPS34 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.4 kDa
20 µg/$150
PIK3C3 / VPS34 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.4 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).