PICALM / CALM

phosphatidylinositol binding clathrin assembly protein

PICALM / CALM is a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PICALM / CALM (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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PICALM / CALM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114834

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.6 kDa

Price:

100 µg/$494

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Human PICALM / CALM Protein (Recombinant GST) (Full Length) - LS-G31097

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

92.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PICALM / CALM Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68177

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.6 kDa

Price:

20 µg/$1,107

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Human PICALM / CALM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81601

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.6 kDa

Price:

20 µg/$150

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