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PICALM / CALM

phosphatidylinositol binding clathrin assembly protein

PICALM / CALM is a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: PICALM, CALM, LAP, CLTH
Target Sequences: NM_007166 NP_009097.2 Q13492

Publications (1)

1
A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs. Stern JA, White SN, Lehmkuhl LB, Reina-Doreste Y, Ferguson JL, Nascone-Yoder NM, Meurs KM. Human genetics. 2014 133:1139-48. (WB; Human) [Full Text Article] [PubMed:24898977] [PMC:PMC4148152] Related Antibodies: LS-B5065.

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PICALM / CALM ELISA Kit
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96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
PICALM / CALM ELISA Kit
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96-Well Strip Plate
Human
1 Plate/$669
PICALM / CALM ELISA Kit
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Custom
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Mouse
1 Plate/$669
PICALM / CALM ELISA Kit
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Custom
96-Well Strip Plate
Rat
1 Plate/$669
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).