PIAS2 / PIASX

protein inhibitor of activated STAT, 2

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

PIAS2 / PIASX (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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PIAS2 / PIASX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105381

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.2 kDa

Price:

100 µg/$494

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PIAS2 / PIASX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100370

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

100 µg/$710

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Human PIAS2 / PIASX Protein (Recombinant GST, N-terminus) (aa385-473) - LS-G60974

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIAS2 / PIASX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89275

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

20 µg/$215

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Human PIAS2 / PIASX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89277

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.2 kDa

Price:

20 µg/$150

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Human PIAS2 / PIASX Protein (Recombinant His, N-Terminal) - LS-G144068

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

68.1 kDa

Price:

50 µg/$419

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Human PIAS2 / PIASX Protein (Recombinant GST) (Full Length) - LS-G31458

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.8 kDa

Price:

2 µg/$439

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