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PIAS2 / PIASX

protein inhibitor of activated STAT, 2

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.

Gene Name:	protein inhibitor of activated STAT, 2
Synonyms:	PIAS2, ARIP3, DAB2-interacting protein, DIP, MIZ, MIZ1, PIAS-NY protein, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, E3 SUMO-protein ligase PIAS2
Target Sequences:	NM_004671 NP_004662.2 O75928

Publications (2)

Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human) [Full Text Article] [PubMed:26937035] [PMC:PMC4836348] Related Antibodies: LS-C108717.

SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human) [Full Text Article] [PubMed:27099310] [PMC:PMC4907222] Related Antibodies: LS-C108717.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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