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PHB / Prohibitin

prohibitin

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Gene Name:	prohibitin
Synonyms:	PHB, PHB1, Prohibitin
Target Sequences:	NM_002634 NP_002625.1 P35232

Publications (4)

Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria. Witkowski A, Joshi AK, Smith S. The Journal of biological chemistry. 2007 282:14178-85. [PubMed:17374604]

Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase. Da Silva-Azevedo L, Jhne S, Hoffmann C, Stalder D, Heller M, Pries AR, Zakrzewicz A, Baum O. The Journal of physiology. 2009 587:655-68. [PubMed:19047200] [PMC:PMC2670087]

Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation. Kakarla M, Puppala VK, Tyagi S, Anger A, Repp K, Wang J, Ying R, Widlansky ME. Cardiovascular Diabetology. 2019 November;18:148. [Full Text Article] [PubMed:31706320] [PMC:PMC6842161]

A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. Chowdhury D, Tangutur AD, Khatua TN, Saxena P, Banerjee SK, Bhadra MP. Journal of translational medicine. 2013 11:130. (IHC, WB; Human) [Full Text Article] [PubMed:23706090] [PMC:PMC3667141] Related Antibodies: LS-C29731.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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