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PGC / Pepsin C

progastricsin (pepsinogen C)

PGC / Pepsin C is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene Name: progastricsin (pepsinogen C)
Family/Subfamily: Protease , Aspartic A1
Synonyms: PGC, Gastricsin, Pepsinogen II, Pepsin C, Progastricsin, Pepsinogen group II, PGII, Preprogastricsin, Urinary pepsinogen 1, Pepsinogen C, Progastricsin (pepsinogen C)
Target Sequences: NM_002630 NP_002621.1 P20142

Publications (1)

1
Regeneration of severely damaged lungs using an interventional cross-circulation platform. Brandon A Guenthart, John D O'Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C Marboe, Katherine Cunningham, Susan P Halligan, Holly M Wobma, Ahmed E Hozain, Alexander Romanov, Gordana Vunjak-Novakovic, Matthew Bacchetta. Nature communications. 2019 May;10:1985. [Full Text Article] [PubMed:31064987] [PMC:PMC6504972]

☰ Filters
Products
Proteins (15)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (9)
PGC / Pepsin C (15)
No (15)
6His, N-terminus (3)
8His, N-terminus (1)
GST (1)
His (4)
His-GST (1)
Myc-DDK (Flag) (5)
Human (10)
Mouse (1)
Rat (2)
293T Cells (2)
E. coli (5)
HEK 293 Cells (5)
Human Cells (2)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
PGC / Pepsin C Protein - Recombinant Pepsinogen C By SDS-PAGE
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E. coli
8His, N-terminus
36.9 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
PGC / Pepsin C Protein - Purified recombinant protein PGC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
40.5 kDa
20 µg/$1,107
PGC / Pepsin C Protein - Recombinant Pepsinogen C By SDS-PAGE
Select
E. coli
His-GST
71.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
HEK 293 Cells
6His, N-terminus
41 kDa
200 µl/$283
Select
HEK 293 Cells
6His, N-terminus
41 kDa
100 µg/$298
PGC / Pepsin C Protein - 12.5% SDS-PAGE of human PGC stained with Coomassie Blue
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Wheat Germ Extract
GST
68.8 kDa
10 µg/$479; 25 µg/$670
PGC / Pepsin C Protein - Recombinant Pepsinogen C By SDS-PAGE
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E. coli
His
42.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
PGC / Pepsin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
PGC / Pepsin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.43 kDa
100 µg/$494
PGC / Pepsin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
PGC / Pepsin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
42.43 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
42.5 kDa
20 µg/$649
Select
E. coli
His
10.9 kDa
50 µg/$721
PGC / Pepsin C Protein
Select
E. coli
6His, N-terminus
41 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
42 kDa
20 µg/$603
Viewing 1-15 of 15 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).