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PGC / Pepsin C

progastricsin (pepsinogen C)

PGC / Pepsin C is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene Name: progastricsin (pepsinogen C)
Family/Subfamily: Protease , Aspartic A1
Synonyms: PGC, Gastricsin, Pepsinogen II, Pepsin C, Progastricsin, Pepsinogen group II, PGII, Preprogastricsin, Urinary pepsinogen 1, Pepsinogen C, Progastricsin (pepsinogen C)
Target Sequences: NM_002630 NP_002621.1 P20142

Publications (1)

1
Regeneration of severely damaged lungs using an interventional cross-circulation platform. Brandon A Guenthart, John D O'Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C Marboe, Katherine Cunningham, Susan P Halligan, Holly M Wobma, Ahmed E Hozain, Alexander Romanov, Gordana Vunjak-Novakovic, Matthew Bacchetta. Nature communications. 2019 May;10:1985. [Full Text Article] [PubMed:31064987] [PMC:PMC6504972]

☰ Filters
Antibodies (82)
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PGC / Pepsin C (121)
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PGC / Pepsin C Antibody - Immunohistochemistry of paraffin-embedded human ovarian cancer tissue using PGC antibody.
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PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
PGC / Pepsin C Antibody - IHC of Pepsin C (F306) pAb in paraffin-embedded human lung carcinoma tissue.
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PGC / Pepsin C Rabbit anti-Human Polyclonal (Phe306) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PGC / Pepsin C Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
4.688 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PGC / Pepsin C Protein - Recombinant Pepsinogen C By SDS-PAGE
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E. coli
8His, N-terminus
36.9 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
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PGC / Pepsin C Goat anti-Pig Polyclonal (Biotin) Antibody
Pig
ELISA, IF, IHC, WB
Biotin Conjugated
100 µg/$896
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PGC / Pepsin C Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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PGC / Pepsin C Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
PGC / Pepsin C Antibody - Immunohistochemical of paraffin-embedded human gastric cancer tissue using PGC Monoclonal Antibody at dilution of 1:200
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PGC / Pepsin C Mouse anti-Human Monoclonal (1G1H3) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$316; 100 µg/$386
PGC / Pepsin C Antibody - Immunohistochemical analysis of Pepsinogen C staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PGC / Pepsin C Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
PGC / Pepsin C Antibody - Immunohistochemistry analysis of Pepsin C antibody in paraffin-embedded human lung carcinoma tissue.
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PGC / Pepsin C Rabbit anti-Human Polyclonal (aa257-306) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (5B7-F11-F4-F3) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (5B7-F11-F4-F3) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (1A6-E11-E4) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (1A6-E11-E4) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Antibody
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (4H4-E9-E4) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Antibody
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PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (4H4-E9-E4) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Antibody
Select
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (4A3-G4-G6) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PGC / Pepsin C Antibody
Select
PGC / Pepsin C Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (4A3-G4-G6) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
PGC / Pepsin C Antibody - Immunochemical staining of human PGC in human stomach with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.
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PGC / Pepsin C Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, WB
Unconjugated, Preservative Free
100 µl/$412
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PGC / Pepsin C Goat anti-Pig Polyclonal (HRP) Antibody
Pig
ELISA, IHC, WB
HRP Conjugated
100 µg/$896
PGC / Pepsin C Antibody - PGII Luminex with 1H5 Capture  and 3C2 Detection  Antibodies. Substrate used: recombinant protein expressed in E.coli corresponding to amino acids 17-388 of human pepsinogen C. (PG II).
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PGC / Pepsin C Mouse anti-Human Monoclonal (OTI1H5) Antibody
Human
Luminex
Unconjugated
100 µl/$434
PGC / Pepsin C Antibody - Western Blot Positive WB detected in: Mouse stomach tissue All lanes: PGC antibody at 3.4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 43, 35 kDa Observed band size: 43, 35 kDa
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PGC / Pepsin C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
PGC / Pepsin C Rabbit anti-Human Polyclonal (aa 17-388) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 121 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).