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PFKFB1 is a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
Gene Name: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
Synonyms: | PFKFB1, 6PF-2-K/Fru-2,6-P2ase 1, HL2K, PFK/FBPase 1, PFRX, F6PK |
Target Sequences: | NM_002625 NP_002616.2 P16118 |
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