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E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
Gene Name: | pellino E3 ubiquitin protein ligase family member 3 |
Synonyms: | PELI3, Pellino-3, Pellino homolog 3, Protein pellino homolog 3, Pellino homolog 3 (Drosophila) |
Target Sequences: | Q8N2H9 Q8N2H9 |
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