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PDZK1

PDZ domain containing 1

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

Gene Name: PDZ domain containing 1
Synonyms: PDZK1, CAP70, CLAMP, NHERF-3, PDZD1, PDZ domain containing 1, NaPi-Cap1, NHERF3
Target Sequences: NM_002614 NP_002605.2 Q5T2W1

Publications (2)

1
Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW. The Journal of biological chemistry. 2005 280:30143-9. [PubMed:15994332]
2
A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. Robichaud JC, Francis GA, Vance DE. The Journal of biological chemistry. 2008 283:35496-506. [PubMed:18842588]

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Proteins (6)
Over-Expression Lysate (2)
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PDZK1 (6)
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GST (1)
His (2)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
PDZK1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
PDZK1 Protein - Purified recombinant protein PDZK1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
56.9 kDa
20 µg/$1,107
PDZK1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
56.9 kDa
100 µg/$494
PDZK1 Protein
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E. coli
His
61.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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293T Cells
Myc-DDK (Flag)
56.9 kDa
20 µg/$150
PDZK1 Protein - 12.5% SDS-PAGE of human PDZK1 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.83 kDa
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).