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PDXP / Pyridoxal Phosphatase
pyridoxal (pyridoxine, vitamin B6) phosphatase
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
| Gene Name: | pyridoxal (pyridoxine, vitamin B6) phosphatase |
| Synonyms: | PDXP, DJ37E16.5, Chronophin, CIN, PLP, PLP phosphatase, PLPP |
| Target Sequences: | NM_020315 NP_064711.1 Q96GD0 |
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