PDK4

pyruvate dehydrogenase kinase, isozyme 4

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

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Products

ELISA Kits (13)

Type

Competitive EIA (1)

Sandwich (11)

Sandwich CLIA (1)

Target

PDK4 (13)

Reactivity

Human (3)

Mouse (3)

Rat (2)

Chicken (1)

Guinea pig (1)

Monkey (1)

Pig (1)

Rabbit (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (10)

Publications

No (13)

Sample Type

Plasma (9)

Serum (9)

Tissue Homogenates (2)

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Rat PDK4 (Sandwich ELISA) ELISA Kit - LS-F21599

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Pig PDK4 (Sandwich ELISA) ELISA Kit - LS-F20822

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Pig

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Mouse PDK4 (Sandwich ELISA) ELISA Kit - LS-F25249

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Guinea pig PDK4 (Sandwich ELISA) ELISA Kit - LS-F47586

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken PDK4 (Sandwich ELISA) ELISA Kit - LS-F47587

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit PDK4 (Sandwich ELISA) ELISA Kit - LS-F47590

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey PDK4 (Sandwich ELISA) ELISA Kit - LS-F47588

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Human PDK4 (Sandwich ELISA) ELISA Kit - LS-F27135

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Mouse PDK4 (Competitive EIA) ELISA Kit - LS-F28940

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Human PDK4 (Sandwich ELISA) ELISA Kit - LS-F20698

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human PDK4 (Sandwich ELISA) ELISA Kit - LS-F33340

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat PDK4 (CLIA) ELISA Kit - LS-F37710

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse PDK4 (Sandwich ELISA) ELISA Kit - LS-F38405

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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