PDHX / Protein X / ProX

pyruvate dehydrogenase complex, component X

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (12)

Type

Over-Expression Lysate (6)

Recombinant (6)

Target

PDHX / Protein X / ProX (12)

Publications

No (12)

Tag

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (7)

Species

Hepatitis B Virus (1)

Human (7)

Mouse (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (2)

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PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125370

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

100 µg/$494

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Hepatitis B Virus PDHX / Protein X / ProX (Recombinant 6His-SUMO, N-terminus) (Full Length) - LS-G136522

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

32.6kDa

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127990

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.91 kDa

Price:

100 µg/$494

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PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117317

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

100 µg/$494

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Human PDHX / Protein X / ProX (Recombinant His) - LS-G3152

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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Mouse PDHX / Protein X / ProX (Recombinant His-T7) (aa222-471) - LS-G25884

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.3 kDa

Price:

10 µg/$285; 50 µg/$467; 100 µg/$747; 200 µg/$932; 1 mg/$2,058; 500 µg/$1,590; 5 mg/$3,263; 2 mg/$2,246

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Human PDHX / Protein X / ProX (Recombinant His-T7) (aa220-468) - LS-G25883

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.2 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human PDHX / Protein X / ProX (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69746

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

20 µg/$1,107

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Human PDHX / Protein X / ProX (Recombinant GST, N-terminus) (aa1-109) - LS-G60640

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85460

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

20 µg/$150

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Human PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85461

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.91 kDa

Price:

20 µg/$150

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Human PDHX / Protein X / ProX (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85462

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

20 µg/$150

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