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PDHX / Protein X / ProX

pyruvate dehydrogenase complex, component X

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: pyruvate dehydrogenase complex, component X
Synonyms: PDHX, DLDBP, E3BP, OPDX, ProX, Protein x, E3-binding protein
Target Sequences: NM_003477 NP_003468.2 O00330

☰ Filters
Products
Antibodies (26)
Primary (26)
PDHX / Protein X / ProX (26)
Human (18)
Mouse (11)
Rat (3)
Monkey (2)
Pig (8)
IHC (7)
IHC-P (3)
WB (26)
ELISA (3)
ICC (1)
IF (4)
IP (1)
Peptide-ELISA (2)
rabbit (24)
mouse (1)
goat (1)
Product Group
IHCPlus (1)
IgG (5)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (25)
AT1E11 (1)
APC (2)
APC Conjugated (2)
Biotin Conjugated (2)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Unconjugated (12)
aa220-468 (8)
aa222-471 (8)
Thr11 (1)
aa1-300 (1)
aa429-459 (1)
aa488-501 (1)
No (26)
PDHX / Protein X / ProX Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (Thr11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$440
PDHX / Protein X / ProX Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa1-300) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
PDHX / Protein X / ProX Antibody - Immunofluorescence analysis of U2OS cells.
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PDHX / Protein X / ProX Antibody - Immunofluorescent analysis of E3BP staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
PDHX / Protein X / ProX Antibody - Western blot of lysate from WiDr cell line, using hPDX1R444. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa429-459) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PDHX / Protein X / ProX Antibody - 1:100 staining human pancreas carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PDHX / Protein X / ProX Antibody - (1 ug/ml) Staining of Human Pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PDHX / Protein X / ProX Goat anti-Human Polyclonal (aa488-501) Antibody
Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
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PDHX / Protein X / ProX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PDHX / Protein X / ProX Antibody - The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PDHX antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: A431 cell lysate Lane 2.: HepG2 cell lysate Lane 3.: 293T cell lysate Lane 4.: LnCap cell lysate
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PDHX / Protein X / ProX Mouse anti-Human Monoclonal (AT1E11) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
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PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
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PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
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PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Mouse Polyclonal (aa222-471) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) Antibody
Pig, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (HRP) Antibody
Pig, Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (FITC) Antibody
Pig, Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (APC, Cy7) Antibody
Pig, Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (Cy3) Antibody
Pig, Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
PDHX / Protein X / ProX Antibody - Western blot of PDHX / Protein X / ProX antibody.
Select
PDHX / Protein X / ProX Rabbit anti-Human Polyclonal (aa220-468) (PE) Antibody
Pig, Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).