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Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Gene Name: | platelet derived growth factor D |
Family/Subfamily: | PDGF , not assigned-PDGF |
Synonyms: | PDGFD, IEGF, MSTP036, PDGF-D, Iris-expressed growth factor, SCDGF-B, SCDGFB |
Target Sequences: | NM_025208 NP_079484.1 Q9GZP0 |
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