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PDGF-AA

platelet-derived growth factor alpha polypeptide

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.

Gene Name:	platelet-derived growth factor alpha polypeptide
Family/Subfamily:	PDGF , not assigned-PDGF
Synonyms:	PDGFA, PDGF-A, PDGF A-chain, PDGF subunit A, PDGF-1, PDGF1
Target Sequences:	NM_002607 NP_002598.4 P04085

Publications (1)

Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. Philip J Spreadborough, Amy L Strong, John Mares, Benjamin Levi, Thomas A Davis. Journal of orthopaedic surgery and research. 2022 September;17:422. [Full Text Article] [PubMed:36123728] [PMC:PMC9484189]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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