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PDE8A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | phosphodiesterase 8A |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP-specific, high affinity |
Synonyms: | PDE8A, Phosphodiesterase 8A, HsT19550 |
Target Sequences: | AF056490 O60658 O60658 |
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