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PDCD1 / CD279 / PD-1
programmed cell death 1
PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
| Gene Name: | programmed cell death 1 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | PDCD1, CD279, HPD-1, HPD-l, PD1, Protein PD-1, SLEB2, PD-1, CD279 antigen, Programmed cell death 1 |
| Target Sequences: | NM_005018 NP_005009.2 Q15116 |
Publications (9)
1
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. Zahn RC, Rett MD, Korioth-Schmitz B, Sun Y, Buzby AP, Goldstein S, Brown CR, Byrum RA, Freeman GJ, Letvin NL, Hirsch VM, Schmitz JE. Journal of virology. 2008 82:11577-88.
[PubMed:18829748]
[PMC:PMC2583661]
Related Antibodies: LS-C40800.
2
Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. Chang WS, Kim JY, Kim YJ, Kim YS, Lee JM, Azuma M, Yagita H, Kang CY. Journal of immunology (Baltimore, Md. : 1950). 2008 181:6707-10.
[PubMed:18981087]
Related Antibodies: LS-C40800.
3
Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations. Jones RB, Yue FY, Gu XX, Hunter DV, Mujib S, Gyenes G, Mason RD, Mohamed R, MacDonald KS, Kovacs C, Ostrowski MA. Journal of virology. 2009 83:8722-32.
[PubMed:19553327]
[PMC:PMC2738181]
Related Antibodies: LS-C40800.
☰ Filters
Products
Proteins
(45)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(41)
Target
PDCD1 / CD279 / PD-1
(45)
Format
Preservative Free
(1)
Publications
No
(45)
Tag
6His, C-terminus
(6)
AVI-6His, C-terminus
(1)
DDK (Flag)-His, C-terminus
(1)
Fc, C-terminus
(7)
GST
(1)
GST, N-terminus
(1)
His
(2)
His, N-Terminal
(4)
His,C-terminus
(4)
His-GST
(1)
His-SUMO
(1)
His-T7
(1)
Human IgG1 Fc
(2)
Human Mutant IgG1 Fc
(1)
mFc, C-terminus
(2)
Mouse IgG2 Fc
(1)
Mouse IgG2a Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Crab-eating macaque
(2)
Cynomolgus monkey
(1)
Human
(33)
Mouse
(7)
Rat
(1)
Source
293T Cells
(1)
CHO Cells
(7)
E. coli
(5)
HEK 293 Cells
(13)
Human
(1)
Human Cells
(8)
Mammalian Cells
(8)
Wheat Germ Extract
(2)
Purification
Purified
(5)
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(28)
Biologically Active
Biologically active
(3)
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.2kD
10 µg/$248; 50 µg/$313; 500 µg/$530; 1 mg/$748
Wheat Germ Extract
GST
58 kDa
2 µg/$439
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
HEK 293 Cells
Myc-DDK (Flag)
29.2 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
31.65 kDa
100 µg/$494
CHO Cells
Human Mutant IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
200 µg/$519
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$498
E. coli
His-GST
57.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His-T7
14.1 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
E. coli
His-SUMO
32.74 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.3kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.3kD
10 µg/$248; 50 µg/$313; 500 µg/$530; 1 mg/$748
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.1kD
10 µg/$266; 50 µg/$343; 500 µg/$1,869; 1 mg/$2,991
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.1kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Human Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Human PDCD1 / CD279 / PD-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78352
293T Cells
Myc-DDK (Flag)
31.65 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
18 kDa
100 µg/$721; 1 mg/$4,513
HEK 293 Cells
His, N-Terminal
~16 kDa
200 µl/$283
HEK 293 Cells
His, N-Terminal
~16 kDa
100 µg/$298
E. coli
His, N-Terminal
16 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315
HEK 293 Cells
His, N-Terminal
~16 kDa (30-40 kDa reducing conditions)
10 µg/$289; 200 µg/$646; 50 µg/$360
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.10 kDa
10 µg/$281; 50 µg/$389
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.0 kDa
10 µg/$281; 50 µg/$389
Viewing 1-25
of 45
product results
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