PCSK1N / PROSAAS

proprotein convertase subtilisin/kexin type 1 inhibitor

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PCSK1N / PROSAAS (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PCSK1N / PROSAAS Protein (Recombinant GST, N-terminus) (aa173-260) - LS-G62276

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PCSK1N / PROSAAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88918

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.37 kDa

Price:

20 µg/$150

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PCSK1N / PROSAAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114361

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.37 kDa

Price:

100 µg/$494

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Human PCSK1N / PROSAAS Protein (Recombinant His) - LS-G2702

Source:

E. coli

Tag:

His

Price:

20 µg/$329; 100 µg/$479; 10 µg/$279; 50 µg/$373; 250 µg/$769; 500 µg/$1,243

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Human PCSK1N / PROSAAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71127

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$1,107

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