PCSK1N / PROSAAS

proprotein convertase subtilisin/kexin type 1 inhibitor

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

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Products

Antibodies (7)

Proteins (5)

ELISA Kits (4)

Type

Over-Expression Lysate (2)

Primary (7)

Recombinant (3)

Sandwich (4)

Target

PCSK1N / PROSAAS (16)

Reactivity

Human (8)

Mouse (4)

Rat (5)

Monkey (1)

Application

IHC (2)

IHC-P (2)

WB (5)

ELISA (2)

Peptide-ELISA (1)

Host

rabbit (5)

mouse (1)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (1)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (6)

Clone

1E9 (1)

Format

96-Well Strip Plate (4)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (4)

Epitope

aa54-103 (4)

aa182-193 (1)

aa221-242 (1)

Publications

No (16)

Sample Type

Plasma (4)

Serum (4)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ PCSK1N / PROSAAS Antibody (aa182-193) LS-B10595

(4.0) Rating

Antibody:

PCSK1N / PROSAAS Goat anti-Human Polyclonal (aa182-193) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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PCSK1N / PROSAAS Antibody (aa54-103) LS-C170303

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PCSK1N / PROSAAS Antibody (aa54-103, HRP) LS-C465969

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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PCSK1N / PROSAAS Antibody (aa54-103, Biotin) LS-C465967

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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PCSK1N / PROSAAS Antibody (aa54-103, FITC) LS-C465968

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PCSK1N / PROSAAS Antibody (clone 1E9) LS-C134062

Antibody:

PCSK1N / PROSAAS Mouse anti-Human Monoclonal (1E9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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PCSK1N / PROSAAS Antibody (aa221-242) LS-C144116

Antibody:

PCSK1N / PROSAAS Rabbit anti-Human Polyclonal (aa221-242) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

200 µg/$1,027

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Human PCSK1N / PROSAAS Protein (Recombinant GST, N-terminus) (aa173-260) - LS-G62276

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse PCSK1N / PROSAAS (Sandwich ELISA) ELISA Kit - LS-F66518

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat PCSK1N / PROSAAS (Sandwich ELISA) ELISA Kit - LS-F66665

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human PCSK1N / PROSAAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88918

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.37 kDa

Price:

20 µg/$150

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PCSK1N / PROSAAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114361

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.37 kDa

Price:

100 µg/$494

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Human PCSK1N / PROSAAS Protein (Recombinant His) - LS-G2702

Source:

E. coli

Tag:

His

Price:

20 µg/$329; 100 µg/$479; 10 µg/$279; 50 µg/$373; 250 µg/$769; 500 µg/$1,243

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Human PCSK1N / PROSAAS (Sandwich ELISA) ELISA Kit - LS-F32545

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human PCSK1N / PROSAAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71127

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$1,107

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Human PCSK1N / PROSAAS (Sandwich ELISA) ELISA Kit - LS-F66960

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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