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PC5 / PCSK5

proprotein convertase subtilisin/kexin type 5

PC5 / PCSK5 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).

Gene Name: proprotein convertase subtilisin/kexin type 5
Family/Subfamily: Protease , Serine S8
Synonyms: PCSK5, HPC6, PC5, PC6A, Prohormone convertase 5, Protease PC6, Proprotein convertase 5, Proprotein convertase 6, SPC6, Subtilisin/kexin type 5, PC6
Target Sequences: NM_006200 NP_006191.2 Q92824

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
PC5 / PCSK5 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His-SUMO (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (2)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
PC5 / PCSK5 Protein - Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 By SDS-PAGE
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E. coli
His, N-Terminal
40.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
PC5 / PCSK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.65 kDa
100 µg/$494
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E. coli
His-SUMO
52.68 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
PC5 / PCSK5 Protein
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Yeast
His
38.7 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
PC5 / PCSK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.65 kDa
20 µg/$150
PC5 / PCSK5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PC5 / PCSK5 Protein - 12.5% SDS-PAGE of human PCSK5 stained with Coomassie Blue
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Wheat Germ Extract
GST
128 kDa
2 µg/$439
Viewing 1-7 of 7 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).