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PAXIP1 / PTIP

PAX interacting (with transcription-activation domain) protein 1

Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.

Gene Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PAXIP1, CAGF29, CAGF28, PAX-interacting protein 1, TNRC2, PAXIP1L, PTIP, PACIP1
Target Sequences: NM_007349 NP_031375.3 Q6ZW49

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
PAXIP1 / PTIP (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
PAXIP1 / PTIP Protein - 12.5% SDS-PAGE of human PAXIP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
113.2 kDa
2 µg/$439
PAXIP1 / PTIP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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HEK 293 Cells
Myc-DDK (Flag)
121.8 kDa
100 µg/$710
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293T Cells
Myc-DDK (Flag)
121.8 kDa
20 µg/$215
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).