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PAX6

paired box 6

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Gene Name: paired box 6
Synonyms: PAX6, AN2, D11S812E, MGDA, Oculorhombin, Paired box 6, Paired box homeotic gene-6, AN, Aniridia type II protein, WAGR, Paired box protein Pax-6
Target Sequences: NM_001604 NP_001595.2 P26367

Publications (1)

1
The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats. Vivien Giszas, Evelyn Strauß, Christoph Bührer, Stefanie Endesfelder. Oxidative medicine and cellular longevity. 2022 June;2022:5769784. [Full Text Article] [PubMed:35693697] [PMC:PMC9175096]

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Products
Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
PAX6 (8)
No (8)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (5)
Rat (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
PAX6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48 kDa
100 µg/$710
PAX6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
54.26 kDa
20 µg/$150
PAX6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48 kDa
20 µg/$215
PAX6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PAX6 Protein - Recombinant  Paired Box Gene 6 By SDS-PAGE
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E. coli
His-T7
18.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
PAX6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
54.26 kDa
100 µg/$494
PAX6 Protein
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E. coli
His, N-Terminal
48 kDa
50 µg/$419
PAX6 Protein - 12.5% SDS-PAGE of human PAX6 stained with Coomassie Blue
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Wheat Germ Extract
GST
73.1 kDa
10 µg/$479; 25 µg/$670
Viewing 1-8 of 8 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).