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B001/B101
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20700 44th Avenue W
Lynnwood, WA 98036
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PAX2
paired box 2
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
| Gene Name: | paired box 2 |
| Synonyms: | PAX2, Paired box homeotic gene 2, Paired box protein Pax-2, PAPRS, Paired box 2, Paired box gene 2 |
| Target Sequences: | NM_003987 NP_003978.2 Q02962 |
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