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PAS Kinase / PASK
PAS domain containing serine/threonine kinase
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
| Gene Name: | PAS domain containing serine/threonine kinase |
| Family/Subfamily: | Protein Kinase , CAMKL |
| Synonyms: | PASK, HPASK, KIAA0135, PAS Kinase, PAS-kinase, STK37, PASKIN |
| Target Sequences: | NM_015148 NP_055963.2 Q96RG2 |
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