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Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
Gene Name: | PARP1 binding protein |
Synonyms: | PARPBP, AROM, C12orf48, PARP1-binding protein, PARI, PARP-1 binding protein, PARP1 binding protein, PCNA-interacting partner |
Target Sequences: | NM_017915 NP_060385.3 Q9NWS1 |
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