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PARP3
poly (ADP-ribose) polymerase family, member 3
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
| Gene Name: | poly (ADP-ribose) polymerase family, member 3 |
| Synonyms: | PARP3, ADPRT-3, ADPRTL2, ADPRTL3, ARTD3, ADPRT3, HPARP-3, PADPRT-3, Poly[ADP-ribose] synthase 3, Poly[ADP-ribose] synthetase 3, PARP-3, Poly [ADP-ribose] polymerase 3, IRT1, NAD+ ADP-ribosyltransferase 3, Poly(ADP-ribose) synthetase-3 |
| Target Sequences: | NM_005485 NP_005476.4 Q9Y6F1 |
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