PARP13 / ZC3HAV1

zinc finger CCCH-type, antiviral 1

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PARP13 / ZC3HAV1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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PARP13 / ZC3HAV1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.3 kDa

Price:

100 µg/$710

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Human PARP13 / ZC3HAV1 Protein (Recombinant GST, N-terminus) (aa601-699) - LS-G62863

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human PARP13 / ZC3HAV1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91176

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.3 kDa

Price:

20 µg/$215

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Human PARP13 / ZC3HAV1 Protein (Recombinant GST) (Full Length) - LS-G34576

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.3 kDa

Price:

2 µg/$439

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