PARN

poly(A)-specific ribonuclease

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

☰ Filters

Products

ELISA Kits (2)

Type

Sandwich (2)

Target

PARN (2)

Reactivity

Human (1)

Mouse (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (1)

Publications

No (2)

Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Select

Human PARN (Sandwich ELISA) ELISA Kit - LS-F7847

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

Select

Mouse PARN (Sandwich ELISA) ELISA Kit - LS-F487

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

40.96 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$588

Viewing 1-2 of 2 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: ELISA Kits

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.