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Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.
Gene Name: | poly (ADP-ribose) glycohydrolase |
Synonyms: | PARG, PARG99 |
Target Sequences: | NM_003631 NP_003622.2 Q86W56 |
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