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Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth.
Gene Name: | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
Synonyms: | PAPSS2, ATP sulfurylase/APS kinase 2, PAPS synthetase 2, Sk2, Sulfurylase kinase 2, SK 2, ATPSK2, PAPS synthase 2, PAPSS 2 |
Target Sequences: | NM_004670 NP_004661.2 O95340 |
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