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PAPSS 1

3'-phosphoadenosine 5'-phosphosulfate synthase 1

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Gene Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: PAPSS1, ATPSK1, PAPS synthase 1, SK1, PAPSS 1, SK 1, Sulfurylase kinase 1, Paps synthetase, PAPSS
Target Sequences: NM_005443 NP_005434.4 O43252

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).