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PAPSS 1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
| Gene Name: | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Synonyms: | PAPSS1, ATPSK1, PAPS synthase 1, SK1, PAPSS 1, SK 1, Sulfurylase kinase 1, Paps synthetase, PAPSS |
| Target Sequences: | NM_005443 NP_005434.4 O43252 |
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