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Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Gene Name: | pregnancy-associated plasma protein A, pappalysin 1 |
Family/Subfamily: | Protease , Metallopeptidase M43 |
Synonyms: | PAPPA, DIPLA1, IGF-dependent IGFBP-4 protease, PAPPA1, PAPA, PAPP-A, Pappalysin-1, ASBABP2, IGFBP-4ase |
Target Sequences: | NM_002581 NP_002572.2 Q13219 |
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