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Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Gene Name: | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) |
Synonyms: | MPP6, MAGUK protein p55T, VAM1, p55T, PALS2, VAM-1, MAGUK p55 subfamily member 6, Protein associated with Lin7 2, Veli-associated MAGUK 1 |
Target Sequences: | AF162130 AAD45919.2 Q9NZW5 |
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