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PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
PAK6 is a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
| Gene Name: | p21 protein (Cdc42/Rac)-activated kinase 6 |
| Family/Subfamily: | Protein Kinase , PAK (STE20) |
| Synonyms: | PAK6, PAK5, p21-activated kinase 6, p21-activated protein kinase 6, PAK-5, PAK-6, p21(CDKN1A)-activated kinase 6 |
| Target Sequences: | NM_020168 NP_064553.1 Q9NQU5 |
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