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PAFAH2 is platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.
Gene Name: | platelet-activating factor acetylhydrolase 2, 40kDa |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PAFAH2, HSD-PLA2, SD-PLA2, Serine dependent phospholipase |
Target Sequences: | D87845 Q99487 Q99487 |
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