PAFAH1B1 / LIS1

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PAFAH1B1 / LIS1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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PAFAH1B1 / LIS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123192

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

100 µg/$494

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Human PAFAH1B1 / LIS1 Protein (Recombinant GST) (Full Length) - LS-G29612

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PAFAH1B1 / LIS1 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59493

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PAFAH1B1 / LIS1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66613

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$1,107

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Human PAFAH1B1 / LIS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78105

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$150

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