PADI4 / PAD4

peptidyl arginine deiminase, type IV

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PADI4 / PAD4 (8)

Publications

No (8)

Tag

6His, N-terminus (2)

GST, N-terminus (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human PADI4 / PAD4 Protein (Recombinant His-T7) (aa1-300) - LS-G25643

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human PADI4 / PAD4 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G32899

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

98.67 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PADI4 / PAD4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69529

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.9 kDa

Price:

20 µg/$1,107

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Human PADI4 / PAD4 Protein (Recombinant GST, N-terminus) (aa2-110) - LS-G62032

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PADI4 / PAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84881

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.9 kDa

Price:

20 µg/$150

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PADI4 / PAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101086

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.9 kDa

Price:

100 µg/$494

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Human PADI4 / PAD4 Protein (Recombinant 6His, N-terminus) (Met1-Pro663) - LS-G140363

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76.2 kDa

Price:

10 µg/$344; 50 µg/$584

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Human PADI4 / PAD4 Protein (Recombinant 6His, N-terminus) (Met1-Pro663) - LS-G39627

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76.2kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353

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