PADI4 / PAD4

peptidyl arginine deiminase, type IV

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

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Products

ELISA Kits (8)

Type

Sandwich (7)

Sandwich CLIA (1)

Target

PADI4 / PAD4 (8)

Reactivity

Human (4)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (7)

Yes (1)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (5)

Serum (5)

Tissue Homogenates (2)

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Human PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F33817

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.188 - 12 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Human PADI4 / PAD4 (CLIA) ELISA Kit - LS-F29859

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Human PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F21746

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.19 - 12 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Human PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F7962

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Monkey PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F46553

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.19 - 12 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Porcine PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F46554

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.188 - 12 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Chicken PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F46552

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit PADI4 / PAD4 (Sandwich ELISA) ELISA Kit - LS-F46555

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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