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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Gene Name: | phosphofurin acidic cluster sorting protein 2 |
Synonyms: | PACS2, KIAA0602, PACS1-like protein, PACS-2, PACS1L |
Target Sequences: | AB011174 BAA25528.1 Q86VP3 |
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