PABPC1 / PABP1

poly(A) binding protein, cytoplasmic 1

Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PABPC1 / PABP1 (5)

Publications

No (5)

Tag

GST (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PABPC1 / PABP1 Protein (Recombinant His-SUMO) (aa1-370) - LS-G21033

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

57.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PABPC1 / PABP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88681

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.5 kDa

Price:

20 µg/$150

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PABPC1 / PABP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117895

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.5 kDa

Price:

100 µg/$494

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Human PABPC1 / PABP1 Protein (Recombinant GST) (Full Length) - LS-G33223

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

97.1 kDa

Price:

2 µg/$439

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Human PABPC1 / PABP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71073

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.5 kDa

Price:

20 µg/$1,107

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