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PA26 / SESN1 is a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | sestrin 1 |
Synonyms: | SESN1, PA26, p53-regulated protein PA26, p53 activated gene 26, SEST1, Sestrin 1, Sestrin-1 |
Target Sequences: | NM_014454 NP_055269.1 Q9Y6P5 |
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