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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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p66 / SHC

SHC (Src homology 2 domain containing) transforming protein 1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Name: SHC (Src homology 2 domain containing) transforming protein 1
Synonyms: SHC1, p46 shc, p52 shc, SH2 domain protein C1, p66, SHCA, SHC, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A
Target Sequences: NM_003029 NP_003020.2 P29353

Publications (1)

1
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L. Scientific reports. 2016 6:29302. (WB; Human) [Full Text Article] [PubMed:27377870] [PMC:PMC4932503] Related Antibodies: LS-C10119.

Filtered by: None
Type
Cell-Based (1)
Cell-Based Phosphorylation (2)
Sandwich (2)
Target
p66 / SHC (5)
Reactivity
Human (4)
Mouse (3)
Rat (4)
Sample Type
Adherent Cell Cultures (3)
Cell Lysates (2)
Plasma (1)
Serum (1)
Tissue Homogenates (2)
Publications
No (5)
Showing 1-5 of 5 results

Mouse/Human/Rat p66 / SHC ELISA Kit (Cell-Based ELISA) - LS-F2304
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate  $490.00
LSBio image for ELISA Kit

Human p66 / SHC ELISA Kit (Sandwich ELISA) - LS-F8286
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate  $670.00
LSBio image for ELISA Kit

Mouse/Human/Rat Phospho-p66 / SHC (Tyr349) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1051
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate  $590.00
LSBio image for ELISA Kit

Mouse/Human/Rat Phospho-p66 / SHC (Tyr427) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1052
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate  $590.00
LSBio image for ELISA Kit

Rat p66 / SHC ELISA Kit (Sandwich ELISA) - LS-F53988
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate  $870.00
LSBio image for ELISA Kit
Showing 1-5 of 5 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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