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P5CR2 / PYCR2

pyrroline-5-carboxylate reductase family, member 2

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH.

Gene Name: pyrroline-5-carboxylate reductase family, member 2
Synonyms: PYCR2, p5CR 2, p5C reductase 2, p5CR2
Target Sequences: NM_013328 NP_037460.2 Q96C36

Publications (1)

1
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. American journal of human genetics. 2015 96:709-19. (WB; Human) [Full Text Article] [PubMed:25865492] [PMC:PMC4570282] Related Antibodies: LS-C115748.

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31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).