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P450SCC / CYP11A1

cytochrome P450, family 11, subfamily A, polypeptide 1

P450SCC / CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.

Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP11A1, Cholesterol 20-22 desmolase, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450C11A1, CYP11A, Cytochrome P450(scc), p450SCC, Steroid 20-22-lyase, CYPXIA1
Target Sequences: NM_000781 NP_000772.2 P05108

Publications (1)

1
Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. O'Shaughnessy PJ, Monteiro A, Bhattacharya S, Fraser MJ, Fowler PA. Molecular human reproduction. 2013 19:177-87. (WB; Human) [PubMed:23197595] Related Antibodies: LS-B3997.

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Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
P450SCC / CYP11A1 (10)
No (10)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (3)
Myc-DDK (Flag) (3)
Bovine (1)
Human (6)
Mouse (1)
Pig (1)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
P450SCC / CYP11A1 Protein - Recombinant Cytochrome P450 11A1 By SDS-PAGE
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E. coli
His
26.6 kDa
10 µg/$282; 50 µg/$447; 1 mg/$2,005; 200 µg/$892; 100 µg/$715; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
P450SCC / CYP11A1 Protein
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E. coli
His-SUMO
72.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
P450SCC / CYP11A1 Protein - 12.5% SDS-PAGE of human CYP11A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
86.5 kDa
2 µg/$439
P450SCC / CYP11A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
60.1 kDa
100 µg/$494
P450SCC / CYP11A1 Protein - Recombinant  Cytochrome P450 11A1 By SDS-PAGE
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E. coli
His-T7
17.4 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
P450SCC / CYP11A1 Protein - Recombinant  Cytochrome P450 11A1 By SDS-PAGE
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E. coli
His-T7
18.0 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
P450SCC / CYP11A1 Protein - Recombinant  Cytochrome P450 11A1 By SDS-PAGE
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E. coli
His-T7
32.5 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
P450SCC / CYP11A1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
P450SCC / CYP11A1 Protein - Purified recombinant protein CYP11A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42 kDa
20 µg/$1,107
P450SCC / CYP11A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
60.1 kDa
20 µg/$150
Viewing 1-10 of 10 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).