OTULIN / FAM105B

family with sequence similarity 105, member B

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

OTULIN / FAM105B (3)

Publications

No (3)

Tag

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Low Endotoxin Level

Low endotoxin level (1)

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OTULIN / FAM105B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107322

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

100 µg/$494

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Human OTULIN / FAM105B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G95030

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

20 µg/$150

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Human OTULIN / FAM105B Protein (Recombinant His) (aa1-250) - LS-G141131

Source:

E. coli

Sequence Length:

249 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

27.5 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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