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Osteocalcin

bone gamma-carboxyglutamate (gla) protein

Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone.

Gene Name: bone gamma-carboxyglutamate (gla) protein
Synonyms: BGLAP, Bone Gla protein, BGP, OC, Osteocalcin
Target Sequences: BG752923 NP_954642.1 P02818

Publications (9)

1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human) [Full Text Article] [PubMed:26982592] [PMC:PMC4794180]
2
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Nature cell biology. 2017 March;19:189-201. (Mouse) [Full Text Article] [PubMed:28218908] [PMC:PMC5580829]
3
R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Knight MN, Karuppaiah K, Lowe M, Mohanty S, Zondervan RL, Bell S, Ahn J, Hankenson KD. Bone research. 2018 August;6:24. [Full Text Article] [PubMed:30131881] [PMC:PMC6089978]
4
Effects of dietary supplementation of arginine-silicate-inositol complex on absorption and metabolism of calcium of laying hens. Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Armagan Hayirli, James R Komorowski, Nurhan Sahin. PloS one. 2018 January;13:e0189329. [Full Text Article] [PubMed:29360830] [PMC:PMC5779645]
5
PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Bo Yu, Lihong Huo, Yunsong Liu, Peng Deng, John Szymanski, Jiong Li, Xianghang Luo, Christine Hong, Jiandie Lin, Cun-Yu Wang. Cell stem cell. 2018 August;23:193-209.e5. [Full Text Article] [PubMed:30017591] [PMC:PMC6322535]
6
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams. eLife. 2020 Jan;9:e50770. [Full Text Article] [PubMed:31958058] [PMC:PMC6970532]
7
Albiflorin Promotes Osteoblast Differentiation and Healing of Rat Femoral Fractures Through Enhancing BMP-2/Smad and Wnt/ß-Catenin Signaling. Jae-Hyun Kim, Minsun Kim, SooYeon Hong, Eun-Young Kim, Hyangsook Lee, Hyuk-Sang Jung, Youngjoo Sohn. Frontiers in pharmacology. 2021 Jul;12:690113. [Full Text Article] [PubMed:34349649] [PMC:PMC8327266]
8
Induction of osteogenesis by bone-targeted Notch activation. Cong Xu , Van Vuong Dinh , Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara E Pitulescu, Ralf H Adams. eLife. 2022 February;11:e60183. [Full Text Article] [PubMed:35119364] [PMC:PMC8880996]
9
Regional specialization and fate specification of bone stromal cells in skeletal development. Kishor K Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H Adams. Cell reports. 2021 July;36:109352. [Full Text Article] [PubMed:34260921] [PMC:PMC8293626]
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Antibodies (127)
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Osteocalcin (127)
Human (91)
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No (127)
Osteocalcin Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Osteocalcin Rabbit anti-Human Polyclonal (aa2-32) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Osteocalcin Antibody - Immunofluorescence of monoclonal antibody to BGLAP on HeLa cell . [antibody concentration 10 ug/ml]
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Osteocalcin Mouse anti-Human Monoclonal (2D4) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
Osteocalcin Antibody - Chondroma
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Osteocalcin Mouse anti-Bovine Monoclonal (OC4-30) Antibody
Chicken, Sheep, Bovine, Rabbit, Goat, Dog, Rat, Pig, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$567
Osteocalcin Antibody - 1:100 staining human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Osteocalcin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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Osteocalcin Mouse anti-Human Monoclonal (aa1-19) (8H12F9H10) Antibody
Human
ELISA
Unconjugated
0.2 mg/$486
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Osteocalcin Mouse anti-Human Monoclonal (aa15-31) (2H9F11F8) Antibody
Human
ELISA
Unconjugated
0.2 mg/$486
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Osteocalcin Rabbit anti-Human Polyclonal (aa37-49) Antibody
Human
ELISA
Unconjugated
1 ml/$378
Osteocalcin Antibody - Western blot analysis of Osteocalcin expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
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Osteocalcin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
Osteocalcin Antibody - Human Osteoblastoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
Fast Shipping
Osteocalcin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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Osteocalcin Mouse anti-Bovine Monoclonal Antibody
Bovine, Human
ELISA, IHC, RIA, WB
Unconjugated
100 µg/$435
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Osteocalcin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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Osteocalcin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
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Osteocalcin Rabbit anti-Human Polyclonal (aa40-49) Antibody
Human
ELISA, ICC
Unconjugated
100 µl/$558
Osteocalcin Antibody - Western blot of recombinant Osteocalcin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Osteocalcin Rabbit anti-Mouse Polyclonal (aa14-95) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
Osteocalcin Antibody - Western blot of recombinant Osteocalcin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Osteocalcin Rabbit anti-Mouse Polyclonal (aa14-95) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588
Osteocalcin Antibody - Western blot of recombinant Osteocalcin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Osteocalcin Rabbit anti-Mouse Polyclonal (aa14-95) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
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Osteocalcin Rabbit anti-Human Polyclonal (aa37-49) Antibody
Xenopus, Chicken, Sheep, Bovine, Horse, Human, Monkey
ELISA
Unconjugated
1 ml/$562
Osteocalcin Antibody - Osteocalcin was detected in paraffin-embedded sections of mouse tibia tissues using rabbit anti-Osteocalcin Antigen Affinity purified polyclonal antibody
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Osteocalcin Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
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Osteocalcin Goat anti-Human Polyclonal (aa81-95) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
Osteocalcin Antibody - Osteocalcin was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti-Osteocalcin Antigen Affinity purified polyclonal antibod
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Osteocalcin Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IHC, IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
Osteocalcin Antibody - Chondroma
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Osteocalcin Mouse anti-Bovine Monoclonal (aa21-31) (OCG2) Antibody
Bovine, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$567
Osteocalcin Antibody - Western blot of recombinant Osteocalcin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Osteocalcin Rabbit anti-Rat Polyclonal (aa11-98) (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
Osteocalcin Antibody - Osteocalcin was detected in paraffin-embedded sections of rat tibia tissues using rabbit anti- Osteocalcin Antigen Affinity purified polyclonal antibody
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Osteocalcin Rabbit anti-Rat Polyclonal Antibody
Rat
Flo, ICC, IHC, IHC-Fr, IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
Osteocalcin Antibody - Human Osteoblastoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
Fast Shipping
Osteocalcin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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Osteocalcin Rabbit anti-Human Polyclonal (aa2-32) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).