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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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Osteocalcin
bone gamma-carboxyglutamate (gla) protein
Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone.
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human)[Full Text Article]
[PubMed:26982592]
[PMC:PMC4794180]
2
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Nature cell biology. 2017 March;19:189-201. (Mouse)[Full Text Article]
[PubMed:28218908]
[PMC:PMC5580829]
3
R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Knight MN, Karuppaiah K, Lowe M, Mohanty S, Zondervan RL, Bell S, Ahn J, Hankenson KD. Bone research. 2018 August;6:24. [Full Text Article]
[PubMed:30131881]
[PMC:PMC6089978]
4
Effects of dietary supplementation of arginine-silicate-inositol complex on absorption and metabolism of calcium of laying hens. Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Armagan Hayirli, James R Komorowski, Nurhan Sahin. PloS one. 2018 January;13:e0189329. [Full Text Article]
[PubMed:29360830]
[PMC:PMC5779645]
5
PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Bo Yu, Lihong Huo, Yunsong Liu, Peng Deng, John Szymanski, Jiong Li, Xianghang Luo, Christine Hong, Jiandie Lin, Cun-Yu Wang. Cell stem cell. 2018 August;23:193-209.e5. [Full Text Article]
[PubMed:30017591]
[PMC:PMC6322535]
6
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams. eLife. 2020 Jan;9:e50770. [Full Text Article]
[PubMed:31958058]
[PMC:PMC6970532]
7
Albiflorin Promotes Osteoblast Differentiation and Healing of Rat Femoral Fractures Through Enhancing BMP-2/Smad and Wnt/ß-Catenin Signaling. Jae-Hyun Kim, Minsun Kim, SooYeon Hong, Eun-Young Kim, Hyangsook Lee, Hyuk-Sang Jung, Youngjoo Sohn. Frontiers in pharmacology. 2021 Jul;12:690113. [Full Text Article]
[PubMed:34349649]
[PMC:PMC8327266]
8
Induction of osteogenesis by bone-targeted Notch activation. Cong Xu , Van Vuong Dinh , Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara E Pitulescu, Ralf H Adams. eLife. 2022 February;11:e60183. [Full Text Article]
[PubMed:35119364]
[PMC:PMC8880996]
9
Regional specialization and fate specification of bone stromal cells in skeletal development. Kishor K Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H Adams. Cell reports. 2021 July;36:109352. [Full Text Article]
[PubMed:34260921]
[PMC:PMC8293626]
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).