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OSMR / IL-31R-Beta

oncostatin M receptor

OSMR / IL-31R-Beta is a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: oncostatin M receptor
Synonyms: OSMR, IL-31R-beta, IL-31R subunit beta, PLCA1, Oncostatin M receptor, OSMRB, IL-31 receptor subunit beta, IL-31RB
Target Sequences: NM_003999 NP_003990.1 Q99650

Publications (4)

1
Dermal Periostin: A New Player in Itch of Prurigo Nodularis. Takashi Hashimoto, Leigh A Nattkemper, Hei Sung Kim, Christina D Kursewicz, Emilie Fowler, Serena M Shah, Sonali Nanda, Rachel A Fayne, Paolo Romanelli, Gil Yosipovitch. Acta dermato-venereologica. 2020 November; [Full Text Article] [PubMed:33236123] Related Antibodies: LS-B11477.
2
Mechanisms of Itch in Stasis Dermatitis: Significant Role of IL-31 from Macrophages. Takashi Hashimoto, Christina Dorothy Kursewicz, Rachel Alison Fayne, Sonali Nanda, Serena Maya Shah, Leigh Nattkemper, Hiroo Yokozeki, Gil Yosipovitch. The Journal of investigative dermatology. 2020 Apr;;140:850-859.e3. [Full Text Article] [PubMed:31626785] Related Antibodies: LS-B11477.
3
Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta. Takashi Hashimoto, Leigh A Nattkemper, Hei Sung Kim, Christina D Kursewicz, Emilie Fowler, Serena M Shah, Sonali Nanda, Rachel A Fayne, John F Paolini, Paolo Romanelli, Gil Yosipovitch. Experimental dermatology. 2021 June;30:804-810. [Full Text Article] [PubMed:33428793] Related Antibodies: LS-B11477.
4
SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation. Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR. Experimental neurology. 2014 254:180-9. (WB; Human) [Full Text Article] [PubMed:24508558] [PMC:PMC4241368] Related Antibodies: LS-C73895.
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Products
Proteins (12)
Over-Expression Cell Culture Supernatant (1)
Recombinant (11)
OSMR / IL-31R-Beta (12)
No (12)
6His, C-terminus (2)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His,C-terminus (1)
His-GST-S (1)
His-T7 (2)
Myc-DDK (Flag) (1)
Human (9)
Mouse (2)
Rat (1)
E. coli (3)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (4)
OSMR / IL-31R-Beta Protein - Recombinant Oncostatin M Receptor By SDS-PAGE
Select
E. coli
His-T7
31.5 kDa
10 µg/$274; 50 µg/$397; 100 µg/$635; 200 µg/$792; 1 mg/$1,864; 500 µg/$1,419; 5 mg/$2,826; 2 mg/$2,047
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
83.7 kDa
200 µg/$926; 1 mg/$2,785
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
82.0 kDa
10 µg/$269; 50 µg/$367
OSMR / IL-31R-Beta Protein - Recombinant  Oncostatin M Receptor By SDS-PAGE
Select
E. coli
His-GST-S
57.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
HEK 293 Cells
6His, N-terminus
81 kDa
200 µl/$283
OSMR / IL-31R-Beta Protein - 12.5% SDS-PAGE of human OSMR stained with Coomassie Blue
Select
Wheat Germ Extract
GST
65.9 kDa
10 µg/$479; 25 µg/$670
OSMR / IL-31R-Beta Protein - Purified recombinant protein OSMR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
40 kDa
20 µg/$1,107
OSMR / IL-31R-Beta Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
82.6 kDa
100 µg/$721
OSMR / IL-31R-Beta Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
HEK 293 Cells
His, N-Terminal
~120 kDa
10 µg/$289; 50 µg/$360; 200 µg/$646
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
82.03kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
OSMR / IL-31R-Beta Protein - Recombinant Oncostatin M Receptor By SDS-PAGE
Select
E. coli
His-T7
31.6 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).